Novel cardiomyocyte-fated progenitors from human iPS cells for cardiac regeneration

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04819
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: Yamashita Jun 京都大学, iPS細胞研究所, 教授 (50335288)
• Research Collaborator: TAKEDA Masafumi 京都大学, ips細胞研究所, 研究員
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 再生医療 / 発生・分化 / 細胞・組織 / 循環器・高血圧 / 移植・再生医療

Outline of Final Research Achievements

Heart is a main target for regenerative medicine. In this study, we aimed at discovering a novel progenitor cell population which can specifically differentiate into cardiomyocytes even under non-specific environments including heart tissue after cell transplantation. We found that CD82-positive cells during human iPS cell differentiation highly effciently (>95%) gave rise to cardiomyocytes after transplantation to mouse/rat animal models (Takeda, Cell Reports, 2018). Currently, we are examining functional improvement of infarct hearts after the cell transplantation. This cell population would be a novel cell source for cardiac regeneration therapy.

Free Research Field

幹細胞生物学・再生医学・循環器内科学