Clarification of the mechanism of sodium retention and renal circulation in heart failure patients.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04834
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tohoku University
• Principal Investigator: Ito Sadayoshi 東北大学, 医学系研究科, 教授 (40271613)
• Co-Investigator(Kenkyū-buntansha): 森 建文 東北医科薬科大学, 医学部, 教授 (40375001) ; 大崎 雄介 東北大学, 医学系研究科, 助教 (40509212)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 腎機能 / 心機能 / 心腎連関 / 腎臓髄質血流量 / 腎うっ血 / ナトリウム利尿 / 体液貯留

Outline of Final Research Achievements

Due to the functional linkage between cardiac function and renal function, a decline in renal function exacerbates cardiac function and a decline in cardiac function exacerbates renal function. Renal congestion is reported to contribute to the decline of renal function in heart failure patients. Regarding the mechanism of kidney failure caused by congestion, although it is suggested that ischemia is involved due to an increase in venous pressure and a decrease in blood flow, it has not been sufficiently elucidated. We have examined the effects of several drugs which is thought to improve body fluid accumulation on cardio renal syndrome models containing stroke-prone spontaneously hypertensive rats and Dahl salt sensitive rats.

Free Research Field

腎臓生理学