2017 Fiscal Year Final Research Report
Novel effects and regulatory mechanisms of adiponectin, and favine
| Project/Area Number |
15H04853
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
福原 淳範 大阪大学, 医学系研究科, 寄附講座准教授 (00437328)
前田 法一 大阪大学, 医学系研究科, 寄附講座准教授 (30506308)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | アディポネクチン / T-カドヘリン / PGI-PLD / Favine / 動脈硬化 / 脂肪肝 |
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| Outline of Final Research Achievements |
Adiponectin accumulated onto the damaged vascular area such as atherosclerotic lesion and exhibited anti-atherosclerotic effect through T-cadherin. Adiponectin has been shown to bind a specific region of T-cadherin with a high affinity. Moreover, present study discovered a novel insight that adiponectin enhances exosome production via T-cadherin, suggesting the adiponectin/T-cadherin system plays a beneficial and protective role against cellular damages.
We herein showed that GPI-PLD was a significant enzyme increasing hepatic DAG, finally causing insulin resistance, and hepatic GPI-PLD was increased in a diabetic condition. Our results suggest that GPI-PLD is a novel therapeutic target for diabetes.We showed that Favine promoted adipocyte differentiation and lipid accumulation in adipocytes. We further described the possibility that Favine modulated inflammation in vessels.
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| Free Research Field |
代謝学
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