2017 Fiscal Year Final Research Report
Identification and characterization of Allergin-1 ligand
Project/Area Number |
15H04862
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Collagenous pathology/Allergology
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Research Institution | University of Tsukuba |
Principal Investigator |
Tahara Satoko 筑波大学, 生命領域学際研究センター, 講師 (20360589)
|
Research Collaborator |
HITOMI Kaori 筑波大学, 医学医療系, 研究員
NIIZUMA Kouta 筑波大学, ヒューマンバイオロジー学位プログラム, 大学院生
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | アレルギー |
Outline of Final Research Achievements |
Allergin-1 is an immunoglobulin-like receptor that contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in the cytoplasmic region and is highly expressed on mast cells in both human and mice. Allergin-1 recuits the Src homology 2 domain-containing tyrosine phoshphatases-1 (SHP-1), which inhibit high-affinity receptor for IgE-mediated signaling in mast cells and suppress IgE-mediated systemic anaphylaxis in mice. To further elucidate the physiological roles of Allergin-1, it is essential to identify the ligand for Allergin-1. To achieve this issue, a chimeric protein consisting of extracellular portion of Allergin-1 fused to Fc portion of human IgG1 was use to detect the Allergin-1 ligand.
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Free Research Field |
免疫学
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