Comprehensive study for pathogenesis of severe drug eruption

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04884
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Niigata University
• Principal Investigator: Abe Riichiro 新潟大学, 医歯学系, 教授 (60344511)
• Co-Investigator(Kenkyū-buntansha): 藤田 靖幸 北海道大学, 大学病院, 講師 (80374437)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 重症薬疹 / 皮膚科学

Outline of Final Research Achievements

1) Mechanism of epidermal cell death in severe drug eruption: We clarified the detailed mechanism of cell death by Annexin A1 / FPR1. MLKL phosphorylation was confirmed in addition to the normal necroptosis pathway RIP1 / RIP3 complex formation.
2) Search for cell death inhibitors targeting Annexin A1 / FPR1: We searched for FPR1 antagonists to be inhibitors of necroptosis. Several candidate substances could be identified. In addition, several drug candidates were identified as existing drugs (drug repositioning).
3) Search for new biomarkers in severe drug eruption: By comparing proteins and gene expression by mass spectrometry and RNA-seq using patient samples, not only at the time of onset but also the onset prediction factor was searched. Several rising candidate markers specific for severe drug eruption were identified.

Free Research Field

皮膚科学