The effect of UV irradiation on development of systemic lupus in mouse model

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04888
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kochi University
• Principal Investigator: SANO SHIGETOSHI 高知大学, 教育研究部医療学系臨床医学部門, 教授 (80273621)
• Co-Investigator(Kenkyū-buntansha): 高石 樹朗 高知大学, 教育研究部医療学系臨床医学部門, 助教 (10303223) ; 中島 喜美子 高知大学, 教育研究部医療学系臨床医学部門, 准教授 (20403892) ; 山本 真有子 高知大学, 教育研究部医療学系臨床医学部門, 助教 (20423478) ; 寺石 美香 高知大学, 医学部, 研究員 (40437736) ; 石元 達士 高知大学, 医学部附属病院, 医員 (40750039) ; 大湖 健太郎 高知大学, 教育研究部医療学系臨床医学部門, 助教 (90595274)
• Co-Investigator(Renkei-kenkyūsha): MIYAKE Kensuke 東京大学, 医科学研究所, 教授 (60229812)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 膠原病 / トール様受容体 / 紫外線照射 / 自然免疫

Outline of Final Research Achievements

We previously demonstrated that topical treatment of mice with TLR7 agonists led to development of lupus-like autoimmunity. Furthermore, the simultaneous UVB irradiation with topical TLR7 stimulation of the skin could facilitate the autoimmunity, prompting us to hypothesize that UVB irradiation-induced HMGB-1 produced by epidermal cells might play an additive role in the development of lupus-like condition. However, no evidence was given regarding the commitment of HMGB-1 in multiple experimental settings. We next explored the effect of UVB irradiation in another lupus model, however, no supporting result was obtained. We concluded that the effect of UVB irradiation was limited to topical TLR7 agonists-treated model. Finally, we demonstrated the two distinct effects of imiquimod, a TLR7 agonist, on development of psoriasis-like dermatitis and lupus-like disease.

Free Research Field

皮膚科学