Neural networks underlying social cognitive impairment in schizophrenia and their plasticity

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04893
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyoto University
• Principal Investigator: Murai Toshiya 京都大学, 医学研究科, 教授 (30335286)
• Co-Investigator(Kenkyū-buntansha): 吉原 雄二郎 京都大学, 医学研究科, 特定助教 (00529464) ; 大石 直也 京都大学, 健康長寿社会の総合医療開発ユニット, 特定講師 (40526878) ; 杉原 玄一 京都大学, 医学研究科, 助教 (70402261)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 神経科学 / 臨床

Outline of Final Research Achievements

Social dysfunction is one of the major therapeutic targets of schizophrenia, and is revealed to be associated not only with deficits of neurocognition but also with those of social cognition. Encouraged by recent advance of human MRI technology as well as accumulating evidence of neuroplasticity, we investigated neural correlates of social dysfunction of schizophrenia, especially focusing on network level pathology. Multiple results were obtained, including supportive evidence for etiological heterogeneity of schizophrenia, as well as neural correlates of objective QOL which are different from those of subjective QOL.

Free Research Field

精神医学