2017 Fiscal Year Final Research Report
Basic research for clinical application of next generation multiparticle therapy
| Project/Area Number |
15H04901
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
沼尻 晴子 (橋井晴子) 筑波大学, 附属病院, 病院講師 (00712845)
水本 斉志 筑波大学, 医学医療系, 講師 (20512388)
奥村 敏之 筑波大学, 医学医療系, 准教授 (50241815)
大西 かよ子 筑波大学, 医学医療系, 講師 (60529832)
石川 仁 筑波大学, 医学医療系, 教授 (70344918)
松本 孔貴 筑波大学, 医学医療系, 助教 (70510395)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 粒子線治療 / 陽子線治療 / 中性子捕捉療法 |
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| Outline of Final Research Achievements |
The translational research in terms of cell survival mechanism and sensitizing effects, exploratory for optimum combination by 2 types of particle therapy, which have different cytotoxic mechanism, were carried out in this study. We found a morphological difference in cells between X-ray and proton therapy combined with cisplatinum. For using analysis on radiation physics, proton therapy showed less normal tissue dose and volume in esophageal and lung cancer patients. In addition, risk of development of secondary cancer were reduced by proton therapy in comparison of X-ray therapy. During this period, we have started 3 clinical trials.
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| Free Research Field |
放射線腫瘍学
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