2017 Fiscal Year Final Research Report
Regulation of radiation sensitivity by a pathway linking DNA repair with cell-cycle control
| Project/Area Number |
15H04902
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIYAGAWA Kiyoshi 東京大学, 大学院医学系研究科(医学部), 教授 (40200133)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 放射線治療生物学 / 放射線感受性 |
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| Outline of Final Research Achievements |
To understand mechanisms that affect radiation sensitivity by linking DNA repair with cell-cycle control, we investigated a role of Rad54B, the protein involved in homologous recombination and p53-mediated G1/S checkpoints, in G0/G1 progression. Our studies revealed that Rad54B promotes expression of cyclin D1 by forming an autonomous regulatory loop with E2F1 and c-Jun and defines timing of the exit from quiescence.
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| Free Research Field |
医学
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