Experimental and clinical study of high dose rate radiotherapy using flattening filter free (FFF) mode of linear accelerator.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04907
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hiroshima University
• Principal Investigator: Nagata Yasushi 広島大学, 医歯薬保健学研究科(医), 教授 (10228033)
• Co-Investigator(Kenkyū-buntansha): 村上 祐司 広島大学, 医歯薬保健学研究科(医), 講師 (10403528) ; 小澤 修一 広島大学, 医歯薬保健学研究科(医), 特任准教授 (20360521) ; 木村 智樹 広島大学, 病院(医), 講師 (90379876)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 放射線腫瘍学 / 体幹部定位照射 / 強度変調放射線治療 / 画像誘導放射線治療 / 高線量率放射線治療

Outline of Final Research Achievements

Experimental study of high dose rate radiotherapy using flattening filter free (FFF) mode of linear accelerator measuring surface skin dose and dose within build-up area was performed. On the other hand, development of a new treatment planning system considering time factor was started using PHITS simulation algorithm.
In clinical application of high dose rate radiotherapy using flattening filter free (FFF) mode of linear accelerator, stereotactic body radiotherapy (SBRT)was applied for early stage lung cancer and liver cancer. Functional images of MRI using Gd-EOB-DTPA was also used for SBRT　of liver cancer. Intensity-modulated radiotherapy (IMRT) using high dose rate radiotherapy　 with flattening filter free (FFF) mode was applied for prostate and head & neck cancer.Volumetric multiple arc therapy (VMAT) was applied for esophageal cancer using high dose rate.

Free Research Field

放射線腫瘍学