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2017 Fiscal Year Final Research Report

Analysis of elimination of non-self and development of Stealth T cells aiming generalized antigen-specific adoptive T cell therapy

Research Project

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Project/Area Number 15H04918
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNagasaki University (2016-2017)
Mie University (2015)

Principal Investigator

IKEDA Hiroaki  長崎大学, 医歯薬学総合研究科(医学系), 教授 (40374673)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywords細胞療法 / 遺伝子治療 / がん / 非自己細胞 / TCR / MHC
Outline of Final Research Achievements

We successfully generated 'Stealth T cells' that lack MHC class I expression as well as endogenous T cell receptor expression along with enforced expression of NY-ESO-1-specific T cell receptor utilizing beta 2 micro globulin-targetted CRISPR-Cas9 and siTCR vector. We showed that these 'Stealth T cells' lost the ability to stimulate allogeneic T cells while maintaining the anti-tumor activity against NY-ESO-1 positive tumors. These results suggested that 'Stealth T cells' will be useful for the adoptive T cell therapy with allogeneic T cells for cancer patients.

Free Research Field

腫瘍免疫学、細胞療法学、遺伝子治療学

URL: 

Published: 2019-03-29  

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