Elucidation of a novel evasive adaptation mechanism against antiangiogenic treatment in colorectal cancer cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04931
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Osaka Prefecture University (2016-2017); The University of Tokushima (2015)
• Principal Investigator: Kondo Shigetada 大阪府立大学, 総合リハビリテーション学研究科, 教授 (40304513)
• Co-Investigator(Kenkyū-buntansha): 増田 清士 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (00457318) ; 二川 健 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (20263824)
• Research Collaborator: TOMIDA Chisato 徳島大学, 大学院医歯薬学研究部・栄養生命科学教育部 ; YANO Chisato 徳島大学, 大学院医歯薬学研究部・栄養生命科学教育部 ; AIBARA Kana 徳島大学, 大学院医歯薬学研究部・栄養生命科学教育部
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: VEGF / VEGF受容体 / 悪性進展 / VEGF分子標的薬 / 浸潤

Outline of Final Research Achievements

VEGF- and its receptor (VEGF-R)-targeted anti-angiogenic therapies are important treatments for colorectal cancer. However, there is increasing evidence that VEGF/VEGF-R inhibitors promote the adaptive and evasive resistance of tumor cells to the therapies. How the cancer cells become resistant remains unclear. We elucidated that VEGF/VEGF-R blockers directly act on tumor cells independently of anti-angiogenic effects, resulting in induction of receptor switching to activate the evasive adaptation. We further found several agents that effectively blocked the evasive mechanism.

Free Research Field

腫瘍生物学