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2017 Fiscal Year Final Research Report

Clarification of genetic factors of endometriosis onset using Japanese standard genome reference and Japonica array

Research Project

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Project/Area Number 15H04978
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

YAEGASHI Nobuo  東北大学, 大学病院, 教授 (00241597)

Co-Investigator(Kenkyū-buntansha) 安田 純  東北大学, 東北メディカル・メガバンク機構, 教授 (00281684)
高橋 史朗  東北大学, 大学病院, 特任准教授 (20365183)
渡部 洋  東北医科薬科大学, 医学部, 教授 (80231009)
鈴木 史彦  東北大学, 医学(系)研究科(研究院), 助教 (20400343)
Co-Investigator(Renkei-kenkyūsha) WATANABE Yoh  東北医科薬科大学, 医学部, 教授 (80231009)
Research Collaborator TOKUNAGA Hideki  
SHIBUYA Yusuke  
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords婦人科腫瘍学 / 子宮内膜症 / 卵巣明細胞癌 / 遺伝要因 / 遺伝子異常
Outline of Final Research Achievements

We clarified that increase of copy number of the region containing ZNF217 gene and HNF1B gene region, decrease of copy number of CDKN2A gene and ARID3A gene region in ovarian clear cell carcinoma (OCCC). A significant peak on long arm of chromosome 8 was also observed in OCCC. We confirmed that amplification of three coagulation - related genes in OCCC. We discovered that APOBEC-related base mutation is a characteristic change in OCCC and reported for the first time that base mutation by APOBEC contributes to the development of OCCC.

Free Research Field

産婦人科学

URL: 

Published: 2019-03-29  

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