Relationship between perioperative neutrophil extracellular trap formation and organ dysfunction

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05004
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: UCHIDA Tokujiro 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (40262183)
• Co-Investigator(Kenkyū-buntansha): 槇田 浩史 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20199657) ; 三高 千恵子 東京医科歯科大学, 医歯(薬)学総合研究科, 非常勤講師 (20126254)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 細胞外トラップ / 周術期腎障害

Outline of Final Research Achievements

Perioperative change in serum double-strand DNA (dsDNA) as a marker reflecting neutrophil extracellular trap concentration was studied. Serum samples were collected at baseline, immediately after surgery, and the day after surgery (POD-1). In patients undergoing elective cardiac surgery, serum dsDNA concentration was significantly increased from baseline to immediately after surgery, and they were reduced by POD-1. The difference in serum creatinine concentration between baseline and POD-1 was correlated with dsDNA concentration on POD-1. We also investigated the relationship between serum dsDNA levels and renal function in patients undergoing lung surgery. Although serum dsDNA levels are significantly elevated on POD-1 in these patients, there were no patients diagnosed as acute kidney injury in this cohort. Further studies are needed to determine the relationship between serum dsDNA levels and renal dysfunction.

Free Research Field

周術期管理医学