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2017 Fiscal Year Final Research Report

Biological synthesis of phosphate ions and its feedback mechanism of osteocyte

Research Project

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Project/Area Number 15H05010
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionHokkaido University

Principal Investigator

AMIZUKA Norio  北海道大学, 歯学研究院, 教授 (30242431)

Co-Investigator(Renkei-kenkyūsha) ODA Kimimitsu  新潟大学, 医歯学総合研究科, 教授 (10122681)
Research Collaborator HASEGAWA Tomoka  
HONGO Hiromi  
YAMAMOTO Tomomaya  
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords骨細胞 / 石灰化 / FGF23 / ENPP1 / TNAP
Outline of Final Research Achievements

αKlotho-/-mice and kl/kl mice prevented the increment of serum phosphate level, when being fed with low-phosphate diets. Low-phosphate diets rescued the reduced mineralization of kl/kl bone but not αklotho-/-bone, indicating that bone mineralization seems to be regulated not only by serum concentration of phosphate, but also other mechanism. In a normal state, steoblasts being about to differentiate into osteocytes localized podoplanin and phsophorylated-ezrin along the cell membranes. ENPP1-/-mice and kl/kl mice prematurely demonstrated many osteoblasts featuring podoplanin and phosphorylated-ezrin. Therefore, the elevated concentration of serum phosphate and/or membrane transporters/enzymes serving for phosphate ion-supplement may be involved in osteocytic differentiation from osteoblasts.

Free Research Field

骨代謝学・細胞組織学

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Published: 2019-03-29  

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