Establishment of tooth regeneration strategy by neural crest cells induced from human iPS cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05037
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: Honda Masaki 愛知学院大学, 歯学部, 教授 (70361623)
• Co-Investigator(Kenkyū-buntansha): 鳥海 拓 愛知学院大学, 歯学部, 講師 (40610308) ; 磯川 桂太郎 日本大学, 歯学部, 教授 (50168283) ; 湯口 眞紀 日本大学, 歯学部, 助手 (00256885)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: tooth regeneration / neural crest cells / iPS cells / tissue engineering / dentin / cementum

Outline of Final Research Achievements

Tooth development is started from the interaction between epithelial and neural crest derived mesenchymal cells. We try to induce human iPS cells into neural crest cells to develop dental tissues. First, we are successfully induced the human iPS cells into neural crest cells. Then, the dentin and cementum formation are successfully generated from transplanted the combination both neural crest cells and dental epithelial cells in tissue engineering methods. These results indicated that the object in this study are almost achieved during three years.

Free Research Field

組織学・発生学