Elucidation of the pathogenic mechanism of diabetic nephropathy by oral microorganism-derived blood TLR ligand and development for prevention

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05060
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Okayama University (2017); Fukuoka Dental College (2015-2016)
• Principal Investigator: SAWA YOSHIHIKO 岡山大学, 医歯薬学総合研究科, 教授 (70271666)
• Co-Investigator(Kenkyū-buntansha): 加藤 幸成 東北大学, 医学系研究科, 教授 (00571811) ; 畠山 雄次 福岡歯科大学, 口腔歯学部, 教授 (40302161) ; 坂上 竜資 福岡歯科大学, 口腔歯学部, 教授 (50215612) ; 福島 秀文 東北大学, 歯学研究科(研究院), 准教授 (70412624)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 歯周病 / 糖尿病性腎症 / toll-like receptor / Porphyromonas gingivalis / 糸球体硬化

Outline of Final Research Achievements

Diabetes is known to increase the possibility of becoming nephropathy when it comes to periodontitis, but the mechanism is not known. In an experiment using diabetic mice, we found that blood vessels of a urine generating device, called glomeruli of the kidney, express 'toll-like receptors' that recognize bacterial components when it comes to diabetes. We also found that injection of periodontal disease pathogen into mucosa of diabetic mouse oral cavity causes nephropathy. It is thought that germs of periodontal disease enter the blood vessels of the oral cavity, go around the body, enter the kidney and bind to the receptor and cause nephropathy. In periodontitis, bacteria easily enter the blood vessel with tooth brushing. For people with diabetes, prevention of periodontitis is considered to prevent the diabetic nephropathy.

Free Research Field

解剖学、脈管学、疫学、分子生物学、腫瘍生物学