2017 Fiscal Year Final Research Report
Study on the balance between protective and regulatory immune responses that determine the pathogenesis of malaria infection in the endemic region of Kenya
Project/Area Number |
15H05277
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 海外学術 |
Research Field |
Parasitology (including sanitary zoology)
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Research Institution | Nagasaki University |
Principal Investigator |
YUI Katsuyuki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90274638)
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Co-Investigator(Kenkyū-buntansha) |
木村 大輔 長崎大学, 医歯薬学総合研究科(医学系), 講師 (50423637)
濱野 真二郎 長崎大学, 熱帯医学研究所, 教授 (70294915)
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Co-Investigator(Renkei-kenkyūsha) |
KANEKO Osamu 長崎大学, 熱帯医学研究所, 教授 (50325370)
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Research Collaborator |
KIJOGI Caroline
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | Malaria / T cells / Cytokine / Africa |
Outline of Final Research Achievements |
Individuals living in malaria endemic areas become clinically immune after multiple re-infections over time and remain infected without apparent symptoms. However, it is unclear how such a balanced status of the infection and immunity is maintained. We conducted a cross-sectional study of the immune responses in asymptomatic school children living in an endemic region of Plasmodium falciparum infections in Kenya. The production of cytokines by peripheral blood mononuclear cells in response to P. falciparum crude antigens exhibited strong heterogeneity among children. In addition, production of IL-2 in response to T-cell receptor stimulation was reduced in children with positive as compared to negative P. falciparum findings. These data suggest that T cell immune responses are generally suppressed among asymptomatic infected children living in the endemic region of P. falciparum,
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Free Research Field |
感染免疫学
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