Sudden cardiac death of young prevalent in Southeast Asia - survey and investigation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05290
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Legal medicine
• Research Institution: Keio University
• Principal Investigator: Fujita Masaki Q. 慶應義塾大学, 医学部(信濃町), 教授 (00211524)
• Co-Investigator(Kenkyū-buntansha): 中嶋 克行 女子栄養大学, 付置研究所, 客員教授 (10444051) ; 大澤 資樹 東海大学, 医学部, 教授 (90213686)
• Co-Investigator(Renkei-kenkyūsha): OKAJIMA Fumikazu 青森大学, 薬学部, 教授 (30142748)
• Research Collaborator: MURAKAMI Masami 群馬大学, 医学部, 教授 ; SIRISUP Nantana チュラロンコン大学, 医学部, 准教授 ; CHUTIVONGSE Panuwat チュラロンコン大学, 医学部, 講師 ; ISLAM Mohammed N. 国立マラ工科大学, 医学部, 教授 ; Myo Thaik Oo ヤンゴン第一医科大学, 医学部, 教授 ; Min Thu ヤンゴン第一医科大学, 医学部, 講師 ; BRUGADA Ramon ジローナ大学, 心臓血管系疾患遺伝子研究所, 教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ポックリ病 / Lai-Tai / 突然死 / 冠動脈攣縮 / 東南アジア / 不整脈 / Brugada症候群 / 脂質代謝

Outline of Final Research Achievements

Pokkuri Death Syndrome (PDS) is a sudden unexpected nocturnal death of unknown cause in mostly young males that has been reported in Japan and other South-Asian countries. We have been investigating Lai-Tai, similar to PDS, in Thailand with our counterpart. And from our study, we estimated that there is approximately 1200 to 1800 Lai-Tai death cases in the whole country. Genetic analysis of SC5NA, responsible for Brugada syndrome and other sudden arrhythmic death was performed in Lai-Tai cases. There were more than one amino acid substitutions in 72% of the Lai-Tai cases, and some mutations seemed to be peculiar to Lai-Tai, which need to be analyzed functionally. We also found similar cases in Myanmar in our collaboration study.

Free Research Field

法医病理学　突然死　客観的法医学的診断