International Collaborative Sutudy for Surrogate Renal Outcomes in Clinical Research

2018 Fiscal Year Final Research Report

• Project/Area Number: 15H05291
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: Yasuda Yoshinari 名古屋大学, 医学系研究科, 寄附講座准教授 (60432259)
• Co-Investigator(Kenkyū-buntansha): 丸山 彰一 名古屋大学, 医学系研究科, 教授 (10362253) ; 堀尾 勝 大阪大学, 医学系研究科, 准教授 (20273633) ; 石井 秀樹 名古屋大学, 医学部附属病院, 講師 (90456674)
• Research Collaborator: ISEKI kunitoshi
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 腎代替アウトカム指標 / GFR / 尿タンパク / IgA腎症

Outline of Final Research Achievements

In Asian collaborative study, we analyzed suitable surrogate renal outcomes for clinical research. First, we established accurate renal function evaluation methods for Korean, Taiwan ,Thai and Indian CKD patients. Second, we analyzed utility of various renal outcomes in Asia. In health-check subject and CKD cohort studies, 30% decrease in eGFR could be surrogate renal outcome instead of hard end point including end stage kidney disease. Among IgA nephropathy patients, 50% increase in serum creatinine was good renal outcome to assess treatment effect and prognosis in renal biopsy. By surveillance of Asian renal outcome studies, GFR decline rate was sensitive and reliable renal outcome.

Free Research Field

腎臓内科

Academic Significance and Societal Importance of the Research Achievements

アジア人種に適した腎機能評価法に基づく腎代替アウトカム指標を用いることで、腎領域における臨床研究が推進できると期待される。本研究を通じたアジア各国との国際共同体制は、日本を中心とした腎領域国際共同研究の基盤となる。