2017 Fiscal Year Annual Research Report
Exploration of the role of environmental chemical (arsenic) in the development of diabetes and the related metabolic disorders for South Asian Countries
| Project/Area Number |
15H05294
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| Research Institution | University of Tsukuba |
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Principal Investigator |
河野 了 筑波大学, 医学医療系, 講師 (90323295)
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| Co-Investigator(Kenkyū-buntansha) |
下條 信威 筑波大学, 医学医療系, 講師 (20462210)
Jesmin Subrina 筑波大学, 人間総合科学研究科, 研究員 (60374261)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 南アジア / 糖尿病 / メタボリック症候群 / ヒ素 / メカニズム |
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| Outline of Annual Research Achievements |
We have completed 3 years of the project with a number of findings for the arsenic affected population in Bangladesh which are potential for the health policy reformulation in Bangladesh. The current study has been mainly conducted in rural Bangladesh which has less focus on health issues. Typical skin lesions of arsenic exposure characterized by keratosis, hyperpigmentation and hypopigmentation have been noted in 72.2% arsenic exposed population in our study. It is evident that arsenic affected population both from cross-sectional and case-control study design are prone to have non-communicable diseases (NCD) namely diabetes, metabolic-syndrome, hypertension. Diabetes, the world greatest epidemic, is highly prevalent in arsenic affected population and is increasing over-time (1998: 4.4% vs. current study 13.2% in 2017) in Bangladesh. In the quartile analysis, more the arsenic concentration of drinking water, greater is the diabetes prevalence in that region. Hypertension prevalence is more than double in arsenic exposed population with skin lesion. In addition, severity and prevalence of the NCD risk factors also depends on the duration of arsenic exposure. The prevalence of obesity in the arsenic exposed population with skin lesion is about 7.2% which is higher in comparison to non-skin lesion population (4.8%). VEGF and its downstream signaling cascade have been intensively investigated revealing VEGF has direct correlation with arsenic exposure and the duration of exposure. In current study, average duration of arsenic exposure having skin lesion is 8.5 years.
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| Research Progress Status |
29年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
29年度が最終年度であるため、記入しない。
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[Journal Article] The differences in the coagulofibrinolytic changes between post-cardiac arrest syndrome of cardiac causes and hypoxic insults2017
Author(s)
Wada, T.;Close author notes Gando, S.; Mizugaki, A.; Kodate, A.; Sadamoto, Y.; Maekawa, K.; Murakami, H.; Katabami, K.; Ono, Y.; Hayakawa, M.; Sawamura, A.; Jesmin, S.; Ieko, M
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Journal Title
Acute Medicine & Surgery,
Volume: 4(3)
Pages: 371-372
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] l Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes.2017
Author(s)
Shima, T.; Matsui, T.; Jesmin, S.; Okamoto, M.; Soya, M.; Inoue, K.; Liu, Y.F.; Torres-Aleman, T.; McEwen, B.S.; Soya, H.
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Journal Title
Diabetologia
Volume: 60(3)
Pages: 597-606
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Prevention of type 2 diabetes mellitus-induced hippocampal cognitive dysfunction from pre-diabetic stage through a 4 months mild exercise regimen.2018
Author(s)
Jesmin, S.; Shima, T.; Takahashi, K.; Omura, K.; Khatun, A.; Matsuishi, Y.; Koizumi, H.; Soya, M1.; Sato, R.; Jangsoo, Y.; Kasane, O.; Matsui, T.; Iwashima, Y.; Yamaguchi, N.; Kawano, S.; Shimojo, N.; Soya, H.
Organizer
2nd General Meeting on Creation and Promotion of WILLDYNAMICS
Int'l Joint Research
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[Presentation] Prevention of type 2 diabetes mellitus-induced hippocampal cognitive dysfunction from pre-diabetic stage through a 4 months mild exercise regimen.2018
Author(s)
Jesmin, S.; Shima, T.; Takahashi, K.; Omura, K.; Khatun, A.; Matsuishi, Y.; Koizumi, H.; Soya, M1.; Sato, R.; Jangsoo, Y.; Kasane, O.; Matsui, T.; Iwashima, Y.; Yamaguchi, N.; Kawano, S.; Shimojo, N.; Soya, H.
Organizer
International ARIHHP Forum
Int'l Joint Research
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[Presentation] Six weeks moderate exercise is effective in ameliorating spatial memory impairment in estrogen-depleted female rat2017
Author(s)
Jesmin, S.; Takahashi, K.; Shima, T.; Matsuishi, Y.; Soya, M.; Yook, J.S.; Ogura, K.; Shimojo, N.; Kawano, S.; Iwashima, Y.; Yamaguchi, N.; Soya, H.
Organizer
International ARIHHP Forum Science week
Int'l Joint Research
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[Presentation] A relatively longer duration of exercise regimen from pre-diabetes prevents spatial memory impairment with improvement of diabetic symptoms in a type 2 diabetic rat model2017
Author(s)
Jesmin, S.; Shima, T.; Takahashi, K.; Matsuishi, Y.; Soya, M.; Yook, J.S.; Koizumi, H.; Soto, R.; Ogura, K.; Shomojo, N.; Kawano, S.; Iwashima, Y.; Yamaguchi, N.; Soya, H.
Organizer
Global Initiative for Sports Neuroscience 2017
Int'l Joint Research
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[Presentation] Exercise from pre-diabetes prevents cognitive impairment with improvement of diabetic symptoms in a type 2 diabetic rat model2017
Author(s)
Jesmin, S.; Shima, T.; Takahashi, K.; Omura, K.; Khatun, A.; Matsuishi, Y.; Koizumi, H.; Soya, M.;Sato, R.; Jangsoo, Y.; Kasane, O.; Matsui, T.; Iwashima, Y.; Yamaguchi, N.; Kawano, S.; Shimojo, N.; Soya, H.
Organizer
Annual meeting of Japanese Society of Physical Fitness and Sports Medicine
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[Presentation] Six weeks moderate exercise is effective in ameliorating spatial memory impairment in estrogen-depleted female rat2017
Author(s)
Jesmin S, Shima T, Takahashi K, Omura K, Khatun A, Matsuishi Y, Koizumi H, Soya M, Sato R, Jangsoo Y, Kasane O, Matsui T, Iwashima Y, Yamaguchi N, Soya H
Organizer
International ARIHHP Forum Science week
Int'l Joint Research
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