2017 Fiscal Year Final Research Report
Quantitaive evalution of dynamic regulation of cancer cell adhesion
| Project/Area Number |
15H05351
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Saitama University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | がん / 緑茶カテキン / 細胞膜 / 反射干渉顕微法 / 力学計測 / 細胞接着 / 界面 / 超解像光学顕微法 |
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| Outline of Final Research Achievements |
In this work, to quantitatively understand dynamic adhesion process of cancer cells, interface structures and mechanical properties of cancer cells have been characterized by using various optical/mechanical measurement techniques together with functional materials. The project gained mainly the following two achievements. (1) New experimental platforms for the quantitative evaluation of cancer cell adhesion was developed, which can be used to identify metastatic ability of cancer cells and to carry out drug screening. (2) Physico-chemical measurement revealed that green tea catechin with galloyl moiety can be physically adsorbed to phospholipid membranes, which leads to the significant stiffening of phospholipid membranes. This finding will be useful to design a new class of drugs for cancer therapy from mechanical viewpoints.
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| Free Research Field |
生物物理化学
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