Identification of "central command" pathways in health and heart failure

2018 Fiscal Year Final Research Report

• Project/Area Number: 15H05367
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Tottori University
• Principal Investigator: KOBA Satoshi 鳥取大学, 医学部, 准教授 (40565743)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 交感神経 / 光遺伝学 / 運動 / セントラルコマンド

Outline of Final Research Achievements

Via in vivo optogenetic experiments and neural tracings combined with immunohistochemistry, we identified central efferent pathways underlying sympathetic adjustments to exercise. A central efferent pathway responsible for excessive sympathoexcitation in heart failure was also found.

Free Research Field

自律神経生理学

Academic Significance and Societal Importance of the Research Achievements

本研究は，CC関連脳部位を「線」で結びつけるという新しい試みから，１９世紀からの学術課題である「運動時交感神経調節の中枢メカニズムの解明」を大きく進めた．また，「脳機能制御」という心疾患に対する未来医療の創出に向けた萌芽となり得る．