Development of synthetic biological tools for modulating metabolic fates of cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05371
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Chemical biology
• Research Institution: The University of Tokyo
• Principal Investigator: Komatsu Toru 東京大学, 大学院薬学系研究科(薬学部), 特任助教 (40599172)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ケミカルバイオロジー / 創薬化学

Outline of Final Research Achievements

We tried to establish a novel synthetic biological systems to control metabolic fates of cells in time scales of seconds to minutes. For the purpose, we applied two independent approaches; (1) controlling the substrate or co-factor concentrations, or (2) controlling the enzymatic functions by small molecule-induced protein oligomerization. Through both approaches, we were able to confirm that the controlling metabolic activity by small molecules will be powerful techniques to understand cellular metabolism or controlling diseases caused by the metabolic malfunctions.

Free Research Field

ケミカルバイオロジー