2019 Fiscal Year Final Research Report
Virtual molecular display by nanoscience and mechatronics for nanobiotechnology
| Project/Area Number |
15H05511
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | Hirosaki University (2017-2019)
The University of Tokyo (2015-2016) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | メカトロニクス / ナノバイオテクノロジー / 分子機械 |
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| Outline of Final Research Achievements |
This research proposed nanobio manipulation method based on the control of Coulomb potential and ion concentration in biological environment. Spatial charge density control by electron beam drawing is a fundamental technology to control the spatial and temporal charge density of biomolecular systems in this research. Our research aims to understand the system of mechanical functions with biomolecular interactions which can be manipulated by potential and ion concentration as desired. This method, which directly manipulates intermolecular interactions, is also applied to the induction of self-assembly phenomena, which is important for the construction of next-generation nanostructured materials.
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| Free Research Field |
ナノバイオテクノロジー
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| Academic Significance and Societal Importance of the Research Achievements |
バイオ環境中の生体分子に界面動電現象や電気化学現象を用いて操作することで，分子の時空間パターニングという基礎課程だけでなく，細胞接着分子の結合状態を操作して細胞内に働いている弾性ひずみエネルギー分布を可視化することや，これまで見ることができなかった接着界面の電気化学的イメージングに応用できることを示すなど，本研究で取り組んできたバーチャル電極を自在に提示，操作する技術は細胞工学やナノバイオテクノロジーなど新しい技術革新が求められている分野に貢献するものである．
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