2017 Fiscal Year Final Research Report
Understanding Organelle homeostasis through phospholipid transport
| Project/Area Number |
15H05595
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Research Collaborator |
ENDO Toshiya 京都産業大学, 総合生命科学部, 教授 (70152014)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | リン脂質 / ミトコンドリア / オルガネラコンタクト / スフィンゴ脂質 |
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| Outline of Final Research Achievements |
In this study, we investigated Intracellular logistics systems for lipid transportation. First of all, we succeeded in developing an experimental system to analyze phospholipid transport between the ER and mitochondria in a test tube. Using this system, we identified novel factors involved in the phospholipid and sphingolipid metabolism. Second, we characterized molecular functions of phospholipid transfer proteins in mitochondria. Importantly, we found that organelles, which have been thought to exist separately, directly tether each other and form pathways for transporting phospholipids. These discoveries provide new aspects that could rewrite the concept of cellular structure.
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| Free Research Field |
細胞生物学
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