The role of HDOI in the relationship between bone and fat.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05646
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Takano Haruko 国立研究開発法人国立循環器病研究センター, 研究所, 研究員 (40532891)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脂肪組織 / ナトリウム利尿ペプチド / 骨形成

Outline of Final Research Achievements

Exercise-induced myokines provide systemic benefits by controlling adipose tissues. However, the relationships between bones and adipose tissues remain to be elucidated. In this study, we analyzed whether periosteum-derived HDOI regulates adipose tissues. After backcrossing to C57BL/6 for 10 generations, we didn’t find any abnormalities in adipose tissues of HDOI-KO mice compared to wild-type mice. Furthermore, HDOI-Tg mice were quite normal in their adipose tissues and showed no metabolic differences even under high-fat diet conditions. Although exercise didn’t induce HDOI directly, mechanical stimulation was required to maintain the expression of HDOI.

Free Research Field

細胞生物学、分子生物学