2017 Fiscal Year Final Research Report
Analyses of regulatory mechanisms of energy homeostasis via free fatty acids receptors
| Project/Area Number |
15H05652
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 脂肪酸 / 受容体 / GPCR / エネルギー代謝 / 肥満 / 糖尿病 |
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| Outline of Final Research Achievements |
In this study, we aimed to elucidate the physiological functions of fatty acid receptors responsible for sensing and controlling energy metabolism. Among fatty acid receptors, we focused on GPR 120, which is a medium long-chain free fatty acid receptor, and attempted to create tissue-specific gene deficient mice to elucidate tissue-specific physiological functions. As a result, we shave generated GPR 120 floxed mouse with LoxP sequence inserted with exon 1 of GPR 120 genomic sequences. We also have successfully obtained GPR120 systemic deficient mice by crossing GPR120 floxed mice with systemic Cre expressing mice. In the future, further research development is expected through acquisition and analysis of deficient mice in various adipose tissues and monocytes in progress.
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| Free Research Field |
分子薬理学
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