2017 Fiscal Year Final Research Report
Analysis of regulation of the biological systems by novel calcium signal transducers
Project/Area Number |
15H05653
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
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Research Institution | The University of Tokyo |
Principal Investigator |
Okamoto Kazuo 東京大学, 大学院医学系研究科(医学部), 特任准教授 (00436643)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | 造血 / 免疫 / 骨代謝 / 赤血球 |
Outline of Final Research Achievements |
Calcium signals play crucial roles in maintaining many biological systems including the skeletal and immune system. A number of proteins with EF hand motif that mediate the biological effects of Ca2+ have been identified so far, but the physiological roles of some of them remain largely unknown. The applicant focused on an EF-hand protein Efp and found that hematopoietic cell-specific deficiency of the Efp gene causes severe abnormalities in multiple tissues such as anemia and bone loss. In this study, I tried to elucidate the biological functions of novel Ca2+ signal transducers, Efp and its homologous gene EfpLG, in hematopoietic cell differentiation and bone metabolism mainly by analyzing the genetically deficient mice.
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Free Research Field |
骨免疫学
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