2016 Fiscal Year Final Research Report
Developing effective combination therapy with ATP competitive tyrosine kinase inhibitors
| Project/Area Number |
15H05666
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
Yasuda Hiroyuki 慶應義塾大学, 医学部(信濃町), 講師 (70365261)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 肺癌 / 分子標的治療薬 / ＡＴＰ濃度 |
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| Outline of Final Research Achievements |
Recently, multiple molecular targeted drugs have been developed.Of these molecular targeted drugs, ATP competitive tyrosine kinase in hibitors improved the prognosis of lung cancer patients. Depending on the findings that ATP concentration of the cancer cells affect the efficacy of the ATP competitive tyrosine kinase inhibitors, we tried to develop a combination therapy with drugs which lower the ATP concentration of cancer cells and ATP-competitive tyrosine kinase inhibitors. By exmaining the effect of multiple druds on the ATP concentration of cancer cells, we have identified several drugs which lower the ATP concentration of cancer cells.
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| Free Research Field |
肺癌
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