• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2016 Fiscal Year Final Research Report

Investigation of the pathogeneisis of myelodysplastic syndromes and its therapeutic biomarkers

Research Project

  • PDF
Project/Area Number 15H05668
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionKyoto University

Principal Investigator

Yoshida Kenichi  京都大学, 医学研究科, 助教 (50738226)

Project Period (FY) 2015-04-01 – 2017-03-31
Keywords骨髄異形成症候群
Outline of Final Research Achievements

RNA sequencing of myelodysplastic syndromes revealed characteristic splicing abnormalities caused by mutations in RNA splicing factors, which were likely to be underlying mechanism of MDS pathogenesis. Gene expression analysis also separated MDS samples into two distinct groups, which were correlated with distinct prognosis. Whole-exome sequencing of serially collected MDS samples depicted complex pattern of clonal evolution in MDS patients with and without therapy. Targeted sequencing of MDS before and after treatment of demethylating agent, azacidine, revealed that most patient achieving complete remission harbored TP53 mutations, suggesting that TP53 mutations could be a therapeutic marker of azacitidine treatment.

Free Research Field

造血器腫瘍

URL: 

Published: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi