Analysis of normal and malignant hematopoietic niche using nove bone marrow humanized mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05669
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Kumamoto University
• Principal Investigator: Takizawa Hitoshi 熊本大学, 国際先端医学研究機構, 特別招聘教授 (10630866)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 造血ニッチ / 造血幹細胞

Outline of Final Research Achievements

Bone marrow that sustains lifelong blood production contains not only blood forming hematopoietic stem cells but also non-hematopoietic cells such as mesenchymal stromal cells to form bone marrow microenvironment, often referred to as niche. It is known to maintain hematopoietic stem cell identity, i.e., self-renewal and multi-lineage differentiation, via fluid factor, adhesion molecule and so on. However, these knowledge have been developed by studying experimental small animals, especially mouse. Relatively little is therefore known about human bone marrow niche, and this project aims to uncover human bone marrow niche using novel experimental animal model.

Free Research Field

感細胞生物学、血液学