2017 Fiscal Year Final Research Report
Identification of biomarkers of autoimmune diseases using HLA imputation
| Project/Area Number |
15H05670
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Osaka University (2016-2017)
Tokyo Medical and Dental University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 遺伝統計学 / HLA遺伝子 / バイオインフォマティクス / ゲノム |
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| Outline of Final Research Achievements |
The major histocompatibility complex (MHC) region at chromosome 6 defines risk of a variety of human complex diseases. The HLA imputation method can computationally impute HLA gene variants from the single nucleotide polymorphism (SNP) genotype data in the MHC region. By constructing the HLA imputation reference panel of the Japanese population (n = 900), we conducted HLA imputation analysis for the genome-wide association study (GWAS) data of autoimmune diseases including rheumatoid arthritis and Graves’ disease, which provided biomarker HLA variants with disease risk.
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| Free Research Field |
遺伝統計学
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