2017 Fiscal Year Final Research Report
Development of atomic structural platform for controlling multi-drug resistant bacteria
| Project/Area Number |
15H05672
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Research Collaborator |
KANECHI Leo 名古屋大学, 大学院医学系研究科
KANAYAMA Takato 名古屋大学, 大学院医学系研究科
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 薬剤耐性菌 / メタロベータラクタマーゼ / 16S rRNA メチルトランスフェラーゼ / 阻害剤 |
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| Outline of Final Research Achievements |
Emergence of multidrug-resistant bacteria is becoming a major clinical threat. To overcome the problem of multidrug-resistant bacteria, it needs to develop new antibacterial agents and treatment. In this study, we aimed to develop new agents targeting for antibiotic resistance proteins produced in bacteria. Inhibition of antibiotic resistance mechanism by chemical compounds is expected to revive the efficacy of already-existing antibiotics. We targeted metallo-beta-lactamases and 16S rRNA methyltransferases, which are involved in carbapenem and aminoglycoside resistance, respectively. we screened for chemical compounds using in silico and in vitro techniques and identified several inhibitor candidates of metallo-beta-lactamases and 16S rRNA methyltransferases.
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| Free Research Field |
細菌学
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