2017 Fiscal Year Final Research Report
The role of a lipid mediator in an interaction between cancer and the host, promoting breast cancer progression
| Project/Area Number |
15H05676
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 脂質メディエーター / スフィンゴシン-１-リン酸 / スフィンゴシンキナーゼ / 癌と宿主 / リンパ節転移 / 乳癌 |
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| Outline of Final Research Achievements |
Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid mediator. We studied the role of S1P in the interaction between cancer and host (tumor microenvironment) utilizing experiments using genetically modified cancer cells and mice of S1P production responsive enzymes and analysis of clinical specimens. Based on the results of this study, it was revealed that both S1P produced by cancer and that produced by the host are important for the cancer progression. Our data showed that S1P concentration in the tumor of breast cancer patients with lymph node metastasis is higher than that without lymph node metastasis.
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| Free Research Field |
腫瘍外科
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