Reconstruction of Neuronal Circuitry by Muse cell transplantation in lacunar stroke

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05680
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: Sakata Hiroyuki 東北大学, 医学系研究科, 非常勤講師 (80722305)
• Research Collaborator: TOMINAGA Teiji ; DEZAWA Mari ; Chan Pak H. ; WATANABE Mika ; FUJIMURA Miki ; NAKAGAWA Atsuhiro ; NIIZUMA Kuniyasu
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 神経再生 / 脳梗塞 / Muse細胞 / 白質再建

Outline of Final Research Achievements

Multilineage-differentiating stress-enduring (muse) cells, subpopulation of bone marrow-mesenchymal stem cells, are endogenous　nontumorigenic stem cells with pluripotency. We transplanted Muse cells into the perilesion brain at 2 weeks after lacunar infarction in immunodeficient mice. Transplantation at the delayed subacute phase showed muse cells differentiated into neural cells, facilitated neural reconstruction, improved functions, and displayed solid safety outcomes over prolonged graft maturation period, indicating their therapeutic potential for lacunar stroke.

Free Research Field

脳神経外科