2016 Fiscal Year Final Research Report
Identification of genes related to signals from transformed cells
Project/Area Number |
15H05990
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Functional biochemistry
|
Research Institution | Hokkaido University |
Principal Investigator |
|
Project Period (FY) |
2015-08-28 – 2017-03-31
|
Keywords | 哺乳類細胞競合 / 細胞死 / がん |
Outline of Final Research Achievements |
Transformed cells surrounded by normal cells are eliminated from epithelium. Since the elimination does not occur under the condition of single culture, there should be some cross-talk signals between normal and transformed cells. From microarray analyses, we identified several genes that is up-regulated inside of normal cells. Prostaglandins were the downstream of a gene identified in the microarray analyses. Furthermore, a prostaglandin attenuated the elimination efficiency of transformed cells, indicating that signals from normal cells are also important to regulate the elimination of transformed cells.
|
Free Research Field |
生物学
|