2016 Fiscal Year Final Research Report
Identification of genes related to signals from transformed cells
| Project/Area Number |
15H05990
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
|
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| Research Institution | Hokkaido University |
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Principal Investigator |
|
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| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Keywords | 哺乳類細胞競合 / 細胞死 / がん |
|---|
| Outline of Final Research Achievements |
Transformed cells surrounded by normal cells are eliminated from epithelium. Since the elimination does not occur under the condition of single culture, there should be some cross-talk signals between normal and transformed cells. From microarray analyses, we identified several genes that is up-regulated inside of normal cells. Prostaglandins were the downstream of a gene identified in the microarray analyses. Furthermore, a prostaglandin attenuated the elimination efficiency of transformed cells, indicating that signals from normal cells are also important to regulate the elimination of transformed cells.
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| Free Research Field |
生物学
|
