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2016 Fiscal Year Final Research Report

Histochemical effects of bisphosphonate on osteocytic lacunar-canalicular system

Research Project

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Project/Area Number 15H06002
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionHokkaido University

Principal Investigator

Kanako Tsuboi  北海道大学, 大学病院, 医員 (50754610)

Project Period (FY) 2015-08-28 – 2017-03-31
Keywords骨細胞 / 糖尿病
Outline of Final Research Achievements

We have examined if bisphosphonate would affect osteoblasts/osteocytes, and also if diabates mellitus would worsen the histological features of osteocytes and bone matrix using in SDT fatty rats mimicking diabates mellitus. Stimulated emission depletion microscopy successfully visualized three dimensional structures of actin filaments within the cytoplasmic processes of osteocytes. SDT fatty rats revealed broad un-mineralized bone matrix including many irregularly-arranged DMP-1-/OCN-immunopositive osteocytes, as well as many α-SMA-positive/CD31-reactive blood vessels in the diaphyseal bone marrow. Taken together, diabetes mellitus appears to influence the histological aspects of osteocytes and vascular endothelial cells.

Free Research Field

口腔外科

URL: 

Published: 2018-03-22  

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