Development of jaw bone resorption suppression technique targeting glutamate transport protein PICK1

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06045
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Tohoku University
• Principal Investigator: Kamano Yuya 東北大学, 大学病院, 助教 (70757260)
• Research Collaborator: EGUSA Hiroshi 東北大学, 大学院歯学研究科, 教授 ; SAEKI Makio 新潟大学, 大学院医歯薬総合研究科, 教授
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 骨代謝

Outline of Final Research Achievements

For severe bone resorption, the development of new therapeutic methods based on the regulate bone metabolism factors is an important issue. In this study, we focused on glutamate, which is a neurotransmitter that has the role of regulating bone metabolism, so we studied PICK1 which bind to AMPA glutamate receptor.
Over-expression of PICK1 significantly promoted osteoclast differentiation of osteoclast precursor cells and PDZ domain binding inhibitor of PICK1 significantly inhibited osteoclast differentiation. On the other hand, over-expression of PICK1 of osteoblast precursor cells did not affect osteoblast differentiation.
From the above, it is suggested that PICK1 does not affect osteoblast differentiation and regulate osteoclast differentiation.

Free Research Field

歯科補綴学