Analysis of inner centromere regulation by the APC/C ubiquitin ligase

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06147
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Genetics/Chromosome dynamics
• Research Institution: The University of Tokyo
• Principal Investigator: Izawa Daisuke 東京大学, 分子細胞生物学研究所, 助教 (70754927)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 染色体 / ユビキチン

Outline of Final Research Achievements

aMany cancer cells have a property called chromosome instability in which changes in the number of chromosomes are caused frequently. It has been reported that the activating factor Cdh1 of the ubiquitin ligase complex APC/C (Anapahse Promoting Complex), which is important for cell division, is also involved in chromosome instability, and even in cells with normal chromosome segregation showed chromosome instability when Cdh1 function is suppressed.
Based on the analysis so far, we discovered that if the function of Cdh1 was suppressed, the functions of inner centromere center factor shugosin and cohesin were reduced. We have also discovered that Cdh1 localizes to the chromosome during cell division. Thus, future analyses are needed to see how Cdh1 regulates shugushin.

Free Research Field

染色体分配