Function of HIFs in the joints and spine

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06170
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Okada Keita 東京大学, 医学部附属病院, 助教 (50759173)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 低酸素誘導因子 / 変形性関節症 / 変形性脊椎症

Outline of Final Research Achievements

Hypoxia inducible factors are known to have an important role in the development p of osteoarthritis. We have reported that HIF-2α is a critical catabolic factor in OA and that HIF-1α is an anabolic factor opposed to its counterpart. Here we have found that HIF-2α has a different role in the superficial zone of the articular cartilage and might be an anabolic factor in this perticular part. Also by using ChIP sequencing and microarray analysis, we found tweleve candidate target genes of HIF-1α which might lead to our better understanding of its anabolic effect in the articular cartilage. Also we have found evidence of HIFs involvement in spondylosis, another important skeletal related degenerative disease.

Free Research Field

軟骨代謝