Mechanism by which masticatry dysfunction induces hippocampal Wnt signal and CaMKIIa disorder

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06191
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Okihara Hidemasa 東京医科歯科大学, 歯学部附属病院, 医員 (80754960)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 記憶・学習機能障害 / 咀嚼刺激低下 / Wnt 3a / CaMKIIa

Outline of Final Research Achievements

Recently, the relation between Wnt signal pathway and Alzheimer 's disease, which is a major symptom of memory and cognitive decline, has been drawing attention. In this study, the control group was fed chow pellets, whereas the experimental　group was fed powder food from 3 weeks to 14 weeks of age. Due to weight difference within two groups, there was a necessity to adjust the amount of food　and taking much time to make models. The procedure of the behavior experiment was able to be acquired. However, at the western blotting, clear bands can not be detected at the present stage, only the tendency of protein expression is currently being obtained. We will continue to conduct experiments in the future and quantify it.

Free Research Field

歯科矯正学