2016 Fiscal Year Final Research Report
Analysis of acid-base regulation of the cochlea toward overcoming of the inner ear disease
| Project/Area Number |
15H06224
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
HIBINO Hiroshi
NAGAMORI Shushi
UETSUKA Satoru
NIN Fumiaki
OGATA Genki
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| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Keywords | pH制御性膜タンパク質 / 内耳 / 蝸牛 / イオン電極法 / 質量分析 |
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| Outline of Final Research Achievements |
The unique ionic environment of endolymph is produced by various ion pumps and transporters in the stria vascularis and spiral ligament. However, acid-base regulation of the inner ear is unclear including the treatment of H+ arose from the pumps to maintain the endolymph. In the present study, (1) 20 pH regulatory membrane proteins were found in the stria vascularis by LC-MS/MS. (2) The in vivo measurement system to monitor the endolymph pH was established in order to investigate the involvement of the pH regulatory proteins in the pH regulation of the inner ear.
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| Free Research Field |
医歯薬学
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