Halogen-based Lewis acid-chiral Lewis base catalysts for enantioselective chlorocyclization and fluorocyclization

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06266
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Synthetic chemistry
• Research Institution: Nagoya University
• Principal Investigator: HORIBE Takahiro 名古屋大学, 工学研究科, 特任助教 (20756655)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: ハロ環化反応 / クロロ環化反応 / フルオロ環化反応 / Lewis塩基 / エナンチオ選択的反応 / カルコゲン触媒

Outline of Final Research Achievements

Enantioselective carbon-halogen bond forming reaction using electrophilic halogen is an useful method for synthesis of enantio-enriched halogenated organic compounds. In this study, we focused on Lewis base-Lewis acid cooperative catats for capturing halogens in order to control their reactivities. In the presence of chalcogen Lewis base-halogen-based Lewis acid, highly reactive halogen could be used for halocyclization without producing byproducts. Moreover, we demonstrated enantioselective chlorocyclization.

Free Research Field

有機合成化学