Maternal administration of hydrogen water might be protective for the lps-induced preterm labor in mice.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06282
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Nagoya University
• Principal Investigator: Nakano Tomoko 名古屋大学, 医学部附属病院, 病院助教 (90754953)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 早産 / 分子状水素

Outline of Final Research Achievements

Intrauterine infection is a common trigger for preterm birth and is also a risk factor for the subsequent development of neurodevelopmental abnormalities in the neonates. Hydrogen water (HW) has been already reported to have both antioxidant and anti-inflammatory action. In this study, it is investigated whether effected uterus tissues in Lipoporysaccharide(LPS)-induced preterm models by Hydrogen water(HW). HW+LPS group was decreased delivery within 24 hours after LPS administration compared with LPS group. IL-6 and TNF-alpha was significantly increased in LPS group compared with control groups, but suppressed in HW+LPS group. Contraction-associated proteins(CAPs), cox-2, connexin43, and oxytocin receptor, were also increased in LPS group compared with control group, but suppressed in HW+LPS group. Metalloproteinase-3(MMP-3), Endothelin-1(ET-1) were same result, too.　Futhermore, Hydrogen water did not show fetal damage.

Free Research Field

周産期