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2016 Fiscal Year Final Research Report

Identification of pancreatic tumor specific stem cell markers

Research Project

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Project/Area Number 15H06334
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKyoto University

Principal Investigator

Maruno Takahisa  京都大学, 医学研究科, 医員 (40760567)

Project Period (FY) 2015-08-28 – 2017-03-31
Keywords膵癌 / 癌幹細胞 / Dclk1
Outline of Final Research Achievements

Pancreatic cancer and Pancreatic intraepithelial neoplasia (PanIN) were formed from Dclk1 positive cells in acinar-to ductal metaplasia (ADM), a tissue characteristic of pancreatitis, and Dclk1 positive cells in ADM were found to be pancreatic cancer progenitor cells.
In addition, Dclk1 positive cells in pancreatic cancer and PanIN provided progeny cells in the tumor, although almost no progeny cells were supplied in normal pancreas. It became clear that Dclk1 was a pancreatic cancer-specific stem cell marker.
Furthermore, by selectively ablating Dclk1 positive cells in pancreatic cancer, large cavities were formed in cancer nodules. The possibility of cancer stem cell target treatment was demonstrated.

Free Research Field

消化器内科

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Published: 2018-03-22  

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