2016 Fiscal Year Final Research Report
Elucidation of the effect of mitochondrial complex I on epithelial mesenchymal transition in breast cancer
| Project/Area Number |
15H06338
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Keywords | がん幹細胞性 / 足場非依存性 / 乳癌 |
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| Outline of Final Research Achievements |
We hypothesized that metabolic function of breast cancer is modified when its mitochondrial complex gene changes, resulting in acquisition of cancer stemness (especially anchorage independent growth ability). We examined anchorage independent growth ability of breast cancer cell line with modified metabolic function. Changes in the metabolism of breast cancer cell line accompanying epithelial mesenchymal transition are under analysis.
We newly identified a gene which is thought to be involved in anchorage independent growth and anoikis resistance. The gene exists downstream of a certain gene related to cell migration ability. We revealed that this gene is involved in cancer stemness via CD44 variant.
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| Free Research Field |
腫瘍学
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