Prognostic factors of diffuse lower-grade gliomas

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06339
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurosurgery
• Research Institution: Kyoto University
• Principal Investigator: Aoki Kosuke 京都大学, 医学研究科, 研究員 (10759773)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 神経膠腫 / 遺伝子異常 / 予後因子

Outline of Final Research Achievements

Diffuse lower-grade gliomas (LGGs) are genetically classified into three distinct subtypes based on IDH mutation and 1p/19q codeletion. However, the subtype-specific effects of additional genetic lesions on survival are largely unknown.　In this study, we revealed the subtype-specific effects of genetic alterations and clinicopathological factors on survival in each LGG subtype, using Cox proportional-hazard regression modeling in our cohort. These results were largely confirmed using the dataset from The Cancer Genome Atlas. Our findings suggest that subtype-specific genetic lesions could stratify patients for better management.

Free Research Field

脳腫瘍