Investigation of a new Wnt5a signaling target in cell proliferation

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06368
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Osaka University
• Principal Investigator: SHOJIMA KENSAKU 大阪大学, 医学系研究科, 招へい教員 (80757211)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: Wnt シグナル経路 / β-カテニン経路 / β-カテニン非依存性経路 / 細胞増殖

Outline of Final Research Achievements

In this study, we identified Egr-1 and c-Fos as a candidate of new Wnt5a signaling targets. These expressions were suppressed in the heart and the liver of adult Wnt5a conditional knockout mice. Moreover, we are now under investigation how the Arl4c, which is identified as a new target by Wnt/β-catenin dependent signaling, is involved in tumorigenesis in pancreatic cancer. We found that Arl4c was expressed in more than 80 % of pancreatic cancer cases immunohistochemically. Inhibition of Arl4c expression reduced pancreatic cancer cells metastasis.

Free Research Field

分子生物学