2017 Fiscal Year Final Research Report
The role of 11be-ta-HSD1 in Dermatoporosis
| Project/Area Number |
15H06375
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Osaka University |
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Principal Investigator |
Saori Ochi 大阪大学, 医学系研究科, 助教 (00597495)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Keywords | 11β-HSD1 / skin / mouse / cortisol / dermatoporosis |
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| Outline of Final Research Achievements |
The mRNA expression of 11β-hydroxysteroid dehydrogenase 1(11β-HSD1)increased at 24 and 48 hours after steroid treatment. Otherwise,the mRNA expression of11β-HSD1 decreased at long time after steroid treatment.
Aged mice or steroid treated-mice were epidermal atrophy and the expression of 11β-HSD1increased inkeratinocytes.
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| Free Research Field |
dermatology
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